Search results for "model [interaction]"
showing 10 items of 1495 documents
Specification of Business Components
2003
Component-based software development is a potential reuse paradigm for the future. While the required technologies for a component-style system development are widely available, for instance Sun's Enterprise Java Beans, a problem inhibits the breakthrough of the component paradigm in business applacation domains: compared to traditional engineering disciplines there is a lack of standardized methods to describe business components. Such a description has to address several aspects: What services are offered and requested by a business component? How can these services be used? Are there any interdependencies between the services of a set of business components? What quality characteristics …
Business Modelling. Languages and Tools
2004
The paper provides an overview of business modelling techniques — both at language and tool level. The basic elements of some most popular business modelling languages are briefly outlined, including the GRAPES-BM language developed by IMCS, University of Latvia. The paper presents also the basic principles, how metamodel based generic modelling techniques can be used for supporting several modelling notations simultaneously.
Asynchronous Runtime Verification of Business Processes
2015
The authors propose a runtime verification mechanism for business processes. This mechanism allows verifying the correctness of business process execution and it runs in parallel with the base processes affecting them insignificantly. The authors have identified the case where the use of business process runtime verification is helpful and applicable. The verification mechanism monitors the business process execution and verifies compliance with the base process description. The verification mechanism prototype was developed and tested in real business processes, as well as limits of runtime verification overhead were evaluated.
Information Systems and Business Strategy
2003
The main purpose of this chapter is to deep into the importance attached to the Information Systems for the proper formulation of the corporate strategy. After introducing the basis of the strategic planning tradition model, which suggests the subordination of the Information Systems (IS) to the Business Strategy, we propose a new model that views the IS as an strategic instrument suited for the strategy formulation stage, rather than operational tools for the strategy control phase. Success in the application of this model we call “Concurrent Business/IS Strategic Planning Model” will closely depend on the consistency, coherence and soundness of the IS, both internal and external. In order…
Business Process Reference Models: Survey and Classification
2006
Within the Information Systems field, reference models are well-known for many years. The aim of this paper is to survey and to describe reference models for business processes. Our analysis of 30 process reference models is based on a framework consisting of criteria such as application domain, used process modeling languages, model's size, known evaluations and applications of process reference models. Furthermore, we identify model domains, which have been dealt with, describe similarities and differences between the available process reference models, and point to open research questions.
From Organization Business Model to Information System: One Approach and Lessons Learned
2011
The system ISTechnology and lessons learned of its use in the business modeling and development of information systems are analyzed in the paper. The system consists of the meta-model and applications. The meta-model enables to define a platform independent business model of the organization. The applications provide the definition and interpretation of the business model. Interpretation of the business model provides functionality of the information system in the selected platform. The lessons learned confirm that the development and maintenance cost of information systems can be significantly reduced by use of the ISTechnology.
An Architecture for Collaborative Scenarios Applying a Common BPMN-Repository
2005
Collaborative business scenarios require a flexible integration of enterprises. To manage inter-organizational business processes, existing concepts for business process management (BPM) need to be adopted and extended. This paper presents a conceptual architecture for cross-enterprise processes’ planning, implementation, and controlling. Core component of the architecture is a distributed repository managing all required data and information, which especially obtains a process-oriented view on collaboration networks. Cross-organizational processes need close coordination among networking partners. This is achieved through the integration of business process models. Thus we further propose …
Expression of stress protein gp96, a tumor rejection antigen, in human colorectal cancer
2000
Preparations of stress protein gp96 from tumor cells are active as tumor vaccines by eliciting immune responses against mixtures of individual tumor peptide antigens which are complexed to gp96. Due to the individual antigenicity of tumors, a vaccine consisting of tumor-derived gp96 has to be prepared individually for each patient from autologous tumor tissue. So far, gp96 expression by human tumors has not been analyzed. Here, we report stable and mostly homogenous expression of gp96 by colorectal cancer, which was enhanced compared to surrounding tumor stroma in 70% to 80% of colorectal cancer specimens. Fewer non-metastatic than metastatic primary cancer specimens showed enhanced gp96 ex…
Human Haemato-Endothelial Precursors: Cord Blood CD34+ Cells Produce Haemogenic Endothelium
2012
Embryologic and genetic evidence suggest a common origin of haematopoietic and endothelial lineages. In the murine embryo, recent studies indicate the presence of haemogenic endothelium and of a common haemato-endothelial precursor, the haemangioblast. Conversely, so far, little evidence supports the presence of haemogenic endothelium and haemangioblasts in later stages of development. Our studies indicate that human cord blood haematopoietic progenitors (CD34+45+144-), triggered by murine hepatocyte conditioned medium, differentiate into adherent proliferating endothelial precursors (CD144+CD105+CD146+CD31+CD45-) capable of functioning as haemogenic endothelium. These cells, proven to give…
Impact of Glutathione Peroxidase-1 Deficiency on Macrophage Foam Cell Formation and Proliferation: Implications for Atherogenesis
2013
Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process. GPx-1 deficiency accelerates atherosclerosis and increases lesion cellularity in ApoE(-/-) mice. However, the distribution of GPx-1 within the atherosclerotic lesion as well as the mechanisms leading to increased macrophage numbers in lesions is still unknown. Accordingly, the aims of the present study were (1) to analyze which cells express GPx-1 within atherosclerotic lesions and (2) to determine whether a lack of GPx-1 affects macrophage foam cell formation and cellular proliferation. Both in situ-hybridization and immunohistochemistry of l…